DISSOLUTION ENHANCEMENT OF IBUPROFEN USING SURFACTANTS
Rahul Deb Chakraborty and *Fuad Laman
Ibuprofen is highly water in-soluble drug. An attempt was taken to study the effect of PEG by using solid solution method. In this experiment Cremophor RH 40 and Cremophor EL was used as solubilizing agent. Capsules were prepared manually and drug release was studied using USP basket method at 50 rpm and controlling the temperature 370C. Distilled water was used as dissolution medium. The amount of drug release was measured form the absorbance of UV spectrophotometer at 264nm. The release of drug was plotted in Higuchi release pattern, zero and first order release pattern. This study showed that Cremophor RH 40 and Cremophor EL have effect the release profile of capsule ibuprofen. From this work it was found that it is possible to increase the release of ibuprofen by using Cremophor RH 40 and Cremophor EL.
Keywords: PEG (Poly Ethylene Glycol), Surfactants.
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