EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 6.222

ICV - 79.57

Abstract

DISSOLUTION ENHANCEMENT OF IBUPROFEN USING SURFACTANTS

Rahul Deb Chakraborty and *Fuad Laman

ABSTRACT

Ibuprofen is highly water in-soluble drug. An attempt was taken to study the effect of PEG by using solid solution method. In this experiment Cremophor RH 40 and Cremophor EL was used as solubilizing agent. Capsules were prepared manually and drug release was studied using USP basket method at 50 rpm and controlling the temperature 370C. Distilled water was used as dissolution medium. The amount of drug release was measured form the absorbance of UV spectrophotometer at 264nm. The release of drug was plotted in Higuchi release pattern, zero and first order release pattern. This study showed that Cremophor RH 40 and Cremophor EL have effect the release profile of capsule ibuprofen. From this work it was found that it is possible to increase the release of ibuprofen by using Cremophor RH 40 and Cremophor EL.

Keywords: PEG (Poly Ethylene Glycol), Surfactants.

[Full Text Article]

SJIF Impact Factor: 6.222

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EJPMR: DECEMBER ISSUE PUBLISHED
December issue has been successfully launched on 1 December 2023.

New Issue Published
Its Our pleasure to inform you that, EJPMR 1 December 2023 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

EJPMR New Impact Factor
Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 5.804 to 6.222, due to high quality Publication at International Level