RADIATION THERAPY COMBINATION OF CISPLATIN INVOLVED IN THE TREATMENT OF CONTRASTING CANCER EPITOME: A REVIEW

*G. Y. Srawankumar Mpharm, P. Varalakshmi PharmD, N. Kalyani PharmD, Dr. D. R. Brahma Reddy Mpharm, PhD and Dr. N.V.S. Praveen MBBS. MD.RT.

ABSTRACT

Cancer is a term used to describe a large group of diseases that are characterized by a cellular malfunction. Healthy cells are programmed to know what to do and when to do it and cancerous cells do not have this programming and therefore grow and replicate out of control, they also serve no physiological function and these cells are now termed as “Neoplasm”. Medically termed as “Malignant neoplasm”. Cancer is collection of disease characterized by abnormal and uncontrollable growth. The destruction of Cancer cells can result from uncontrolled cell growth and loss of cell affinity to undergo apoptosis. There are numerous numbers of cancers which can be caused to any type of cell in the organs of the body. Cancer diagnosis can be done with biopsy, endoscopy, blood test, bone marrow aspiration and genetic analysis. Treatment for cancer involves surgery, chemotherapy, Radiation therapy, targeted therapy and immunotherapy. Radiation therapy can be used in combination of cisplatin. Cisplatin is one of the most effective anticancer agents widely used in the treatment of solid tumors and generally considered as cytotoxic drugs which kills cancer cells by damaging DNA and inhibiting DNA synthesis. Combination of cisplatin and Radiation therapy in squamous cell carcinoma has highest success rate.

Keywords: Cancer, radiation, contrasting cancer, clinical manifestations, myeloma, myeloid leukemia, astrocytoma, Kaposi sarcoma, chemotherapy, Radiation therapy, brachytherapy, external radiation.