EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

METHANOLIC BARK EXTRACT OF Sterculia villosa ATTENUATE THE INTRACELLULAR LEISHMANIAL LOAD THROUGH NITRIC OXIDE GENERATION AND IMMUNOMODULATION

Antu Das, Junaid Jibran Jawed, Manash C Das, Akshay Daware, Chinmoy Ghosh, Shukdeb Acharjee, Surajit Bhattacharjee*

ABSTRACT

Visceral leishmaniasis is an immunosuppressive disease caused by the protozoan parasite Leishmania donovani. Visceral leishmaniasis affects millions of people all over the world, especially in subtropical countries. Presently available drugs against visceral leishmaniasis are restricted due to their higher toxicity. This condition further aggravated due to the development of resistance of the parasites against the available drugs. Nowadays several ethnobotanical plant extract are in use for treatment of the protozoan diseases. Sterculia villosa is an ethnomedicinal plant and possess antimicrobial, antiprotozoal property. In the present study methanolic bark extract of Sterculia villosa (SVE) was prepared to evaluate its antileishmanial and immunomodulatory activity. To evaluate its antileishmanial study, intracellular parasitic burden, nitric oxide (NO) generation and cytokine production was studied in L. donovani infected murine peritoneal macrophages. It was observed that SVE inhibited the intracellular parasitic load in the murine peritoneal macrophages and IC50 dose was found to be 50 μg/mL. It was also observed that SVE induces killing of intracellular parasite by up regulating pro-inflammatory and down regulating anti-inflammatory cytokine release. The present study explores that SVE at IC50 dose can induce parasite killing through modulation of cytokine expression and NO generation in comparison with un-treated infected macrophages.

Keywords: Leishmania donovani, SVE, amastigotes, nitric oxide, cytokines.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing