IN PROCESS TESTING FOR SUSTAINED RELEASE BEADS

Durga Rathod, Fatteshwar Pote*, Gayatri Dukare, Harshdeep Pandey, Dr. Chetan Ghulaxe

ABSTRACT

Novel Drug Delivery Systems (NDDS) are advanced approaches designed to deliver drugs at the right site, at the right time, and in the right concentration to achieve maximum therapeutic effect with minimal side effects. Unlike conventional dosage forms (tablets, capsules, injections), NDDS aim to overcome limitations such as poor bioavailability, frequent dosing, and fluctuating plasma drug levels. These systems use modern carriers like microspheres, nanoparticles, liposomes, niosomes, transdermal patches, implants, and beads to control the release, target specific sites, or protect drugs from degradation. NDDS can provide sustained, controlled, or targeted release, which improves patient compliance, reduces side effects, and enhances the overall safety and efficacy of therapy. Sodium alginate has been used as a matrix material to achieve controlled-release drug delivery due to its hydrogel forming properties. The ability of alginate sodium salt, to rapidly form viscous solutions and gels on contact with aqueous media has been exploited by the pharmaceutical industry in sodium alginate’s wide application as a carrier in hydrophilic matrix controlled-release oral dosage forms. Matrices incorporating alginate salts have been employed to successfully prolong the release of many drugs. Evaluation parameters and in process testing of sodium alginate, Stability studies ensuring the maintenance of product quality, safety and efficacy throughout the shelf life are considered as pre-requisite for the acceptance and approval of any pharmaceutical product. Various parameters like size, friability, drug loading, swelling index, mathematical models of release kinetics.1

Keywords: Sodium alginate, Microbeads, NDDS, In-process Testing, Evaluation Parameter, Release kinetics.