BILOSOMES: SUPERIOR VESICULAR CARRIER TO ENHANCE ORAL AND TRANSDERMAL DRUG DELIVERY OF POORLY SOLUBLE ACTIVE DRUG MOLECULES

Harshini M.* and Pilli Archana

ABSTRACT

Many pharmaceutical drugs, peptides and vaccines have less solubility/degradation in GIT due to this after oral intake permeation into systemic circulation is not significant, which in turn effects their pharmacological action. Vesicular drug delivery by liposomes and niosomes can defend entrapped agent to certain extent from degradation. Even though gastro intestinal environment pH, enzyme degradation limits their capability. Similarly, in transdermal route stratum corneum is the major barrier for permeation. In view of all these concerns BS-vesicles were developed by researchers. This review is based on out and out overview of BS-vesicles as a superior pharmaceutical carrier through oral delivery and transdermal of biological therapeutic macromolecules, poorly soluble drugs and vaccines. Insights all the possible research done on the BS-vesicles and their applications, characterization, storage. In addition, methods of preparation and modified BS-vesicles are described. Lastly, the gap in the scientific researches tackling bilosomes that needs to be addressed is highlighted.

Keywords: BS-vesicles, lipophilic drugs, Bile salts, proteins and peptides, vesicular carriers, transdermal route.