ANTICOAGULANT ACTIVITIES OF SEVERAL ACTIVE COMPOUNDS FROM MEDICINAL PLANTS: A REVIEW

Wida Nurhamidah, Gina Desfina Wijaya, Shania Nurshazidah, Adiva Nafila Zulfa, Chaerunnisa, Siti Solihat, Kirana Azzahra Emil Musa, Erisa Mindawati, Yeni Ari Safitri Dalimunthe, Riana Ardianti, Kamelia Risna, Depita Nurapni, Nurhalimah, Fajar Adi Prasetya, Ali Alfarizzy, Muhamad RifqiSyah and Maulana Yusuf Alkandahri*

ABSTRACT

Anticoagulants are classified as pharmaceutical agents that inhibit the development and expansion of clots. Despite its well-documented safety profile and extensive therapeutic efficacy against a wide range of diseases, this medication does possess perilous adverse effects. As a result, medicinal plants can be utilized as an alternative to anticoagulants due to their ability to mitigate potentially harmful side effects. A review of anticoagulant-active compounds derived from a variety of medicinal plants is the subject of this study. The anticoagulant properties of compounds derived from medicinal plants were assessed, including kaempferol, curcumin, luteolin, catechin, quercetin, andrographolide, and piperine. Multiple research studies have provided evidence that these compounds possess the ability to impede blood clotting via diverse mechanisms of action. The implications of these results for the development of novel anticoagulants derived from medicinal plants are significant.

Keywords: Anticoagulants, Kaempferol, Curcumin, Luteolin, Catechin, Quercetin, Andrographolide, Piperine.