THREE BIOMARKERS TO EARLY DETECT COLORECTAL CANCER
*Mohammed Mutlaq Alanazi, Abdullah Bandar Almutairi and Nami M. Aljehani
Objective: Unusual methylation is one of the most frequent epigenetic modifications that can add to tumor development. Cell-free DNA can start from tumor tissue; in this manner, assessing methylation markers in cell-free DNA can be a promising strategy for malignancy screening. Our point was to find a strategy by comparing many studies to gather, to find promising biomarkers. Septin-9 gene (SEPT9), Syndecan-2 gene (SDC2) and Secreted frizzled-related protein 1 gene (SFRP1) are suitable biomarkers with different degrees of sensitivity and specificity for early detection of Colorectal cancer (CRC) by plasma sample. Materials and Methods: This literature review focuses on 2016 to 2020 for biomarkers and CRC early detection. Many websites were used, like PubMed, WHO, nature, and google scholar. The termers used in the research were marker or biomarker, SEPT9, Syndecan-2 gene (SDC2) and Secreted frizzled-related protein 1 gene (SFRP1) biomarkers, CRC diagnosis or screening, and colorectal or colon or rectal cancer. Many markers and methods have different sensitivity and specificity rates. Results: SEPT9, SDC2, and SFRP1 are promising biomarkers for the early detection of CRC. The combination of one or two biomarkers will increase the sensitivity and specificity detection rates. Conclusion: The outcomes from this review are that SEPT9, SDC2, and SFRP1 are promising biomarkers for detecting CRC. The combination between methylation biomarkers and traditional laboratory tests for CRC detection will increase the sensitivity and specificity. Our recommendation is to do these tests Epi pro Colon test, Colo Defense test, and Illumina human methylation test for CRC early detection in Saudi Arabia for patients from 30-40 years old and risk grope peoples. In this way, SEPT9, SDC2, and SEFR1 can turn into an incredible, for early CRC screening of high sensitivity and specificity.
Keywords: Septin-9 gene (SEPT9), Syndecan-2 gene (SDC2), Secreted frizzled-related protein 1 gene (SFRP1), Colorectal cancer (CRC).
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