REVIEW ARTICLE ON ORAL DISPERSIBLE TABLETS (ODT’S): NOVEL TECHNOLOGY, DEVELOPMENT, AND EVALUATION

Pooja P. Kulkarni*, Gururaj S. Kulkarni and Padmaa M. Paarakh

ABSTRACT

The most common and preferred route of administration of drugs is through the oral route. Oral dispersible tablets are gaining more importance among novel oral drug-delivery systems as they have improved patient compliance and have some additional advantages compared to other oral formulations. A new dosage form known as an orally disintegrating tablet (ODT), has been developed which rapidly disintegrates & dissolves in saliva and is then easily swallowed without water which is a major benefit over the conventional dosage form. Thus this type of drug delivery helps a proper peroral administration in paediatric and geriatric populations where trouble arises in swallowing. Various scientists have prepared oral dispersible tablets by following various methods. However, the most common method of preparation is the compression method. Other special methods are moulding, melt granulation, phase-transition, sublimation, freeze-drying, spray-drying, and effervescent method. Since these tablets dissolve directly in the mouth, so, their taste is also an important factor. Various approaches have been to mask the bitter taste of the drug. Several scientists have explored several drugs in this field. The oral dispersible tablets are evaluated for hardness, wetting time, friability, moisture uptake, disintegration test, and dissolution test.

Keywords: ODT?s, Disintegration, Dissolution, Bioavailability.