EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

HISTOLOGICAL CHANGES IN THE HIPPOCAMPUS AND BEHAVIOR PATTERN FOLLOWING EXPOSURE TO PAINT FUMES ON ADULT MALE WISATR RATS

*Ekundina V.O., Ebeye O. A. and Cookey-Gam T.B.

ABSTRACT

People get exposed to paint fumes either as a result of remodeling of homes, nature of occupation and otherwise. Paint fumes are gaseous emissions from paints that get mixed up with the air around us and they contain volatile organic compounds which are known to be hazardous to human health. This study accessed the effect of paint fume exposure on 12 adult male wistar rats divided into 4 groups with 3 rats each. Group 1, 2 and 3 were exposed for 2, 3, and 4 weeks respectively while group 4 was the control group. At the end of each week, open field test was conducted to access some behavioral pattern in the rats. Animals were sacrificed using cervical dislocation, the brain dissected and the hippocampus was fixed, processed using routine processing schedule, paraffin sections were stained with H & E staining technique. Result showed in no observable cellular change in group 1 and group 4, while group 2 showed slight cellular changes in group 2 and marked degenerative changes in group 3. This duration dependent changes in the hippocampus may be as a result of prolonged exposure to paint fumes. Weight showed no marked and statistically variation across all groups, open field test revealved reduced locomotion, exploratory and increased anxiety across the exposed groups when compared with the control. This researched showed that exposure to paint fume caused degenerative changes in the hippocampus which may lead to amnesia and can also be anxiogenic. The public should beware and employ protective measures

Keywords: Hippocampus, Paint Fumes, Open Field Test, Histology, Vocs, Wistar Rat.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )