EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FREQUENCY OF THYROID DYSFUNCTION IN NEWLY DETECTED ADULT PATIENTS WITH TYPE 2 DIABETES MELLITUS ATTENDING A TERTIARY CARE HOSPITAL OF BANGLADESH

Ashim Dhar*, Jobaida Naznin, Muhammad Abdul Halim Khan, Devjani Banik, Mohammad Fariduddin, Muhammad Abul Hasanat and Shahjada Selim

ABSTRACT

Background: Thyroid dysfunction and diabetes mellitus (DM) are the two common endocrinopathies but neither causally related nor mutually exclusive. Coexistence of these two conditions is important for management of both the problems. Objectives: To see thyroid dysfunction in newly detected type-2 DM. Materials and Methods: This cross-sectional study was carried out on newly detected type-2 DM patients [n=200, m/f: 81/119; age: 41.1±8.3; BMI (kg/m2): 26.0±4.2; mean±SD] recruited consecutively from the department of Endocrinology, BSMMU. History and relevant clinical examination were recorded. Free thyroxine (FT4), thyroid stimulating hormone (TSH), anti-TPO and anti-TG antibody were tested Chemiluminescence Immunoassay System (Germany). Results: Thyroid dysfunction was observed in 13% subjects. Most of them had subclinical hypothyroidism (8.5%) followed by overt hypothyroidism (3%), subclinical thyrotoxicosis (1.0%) and hyperthyroidism (0.5%). Only 11.5% had family history of thyroid disorder among subjects having dysfunction. About 11% subjects were anti-thyroid antibody positive. Highest frequency for positive anti-thyroid antibody (87.5%) was observed in group having TSH ≥10 m IU/L followed by 66.7% in the group having TSH (5-10) m IU/L, while only 2.8% in the group having TSH <5 m IU/L (p<0.001). There was no significant difference either for level of FT4 (14.0±4.5 vs 14.1±2.2 vs 13.9±1.5; p= 0.925) or for TSH (3.4±5.0 vs 3.7±9.7 vs 2.3±1.6; p= 0.691) or for the antibody status (p= 0.721) among different levels of HbA1c. No significant correlations of FPG, 2Hr75gPPG and HbA1c was found with any of FT4, TSH, anti-TPO and anti-TG antibodies (p= NS for all). Logistic regression revealed anti-TPO antibody as independent predictor for thyroid dysfunction in subjects with diabetes mellitus (p<0.001). Conclusions: The results of the present study suggest that the thyroid dysfunction is not uncommon in newly diagnosed type-2 DM. Thyroid autoimmunity is one of the predictors for increased risk of thyroid dysfunction in them. Screening for thyroid dysfunction may be wise in newly diagnosed type-2 DM.

Keywords: Thyroid dysfunction, Diabetes mellitus, Hypothyroidism.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 September 2022 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

  • EJPMR: SEPTEMBER ISSUE PUBLISHED

    SEPTEMBER Issue has been successfully launched on 1 September 2022.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database