EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DIAGNOSTIC AND THERAPEUTIC CHALLENGES IN A RARE CASE FLORID CUSHING’S SYNDROME DUE TO ECTOPIC ACTH SECRETION FROM BRONCHIAL CARCINOID AND EMPTY SELLA: A CASE REPORT

Dr. Samia A. Bokhari, Dr. Patan Murthuza Khan, Dr. Shahad J. Ashgar*, Dr. Bashayer B. Almalki,
Dr. Muneera Al Shareef and Dr. Saeed J Alzahrani

ABSTRACT

Objective: Ectopic Cushing’s syndrome (EAS) is a rare disorder. The incidence of EAS varies from .2- 5 cases per million per year. The Ectopic Adrenocarticotrophic harmone(ACTH) secretion primarily from small cell carcinoma and carcinoid of lung. Chronic hypercortisolism due to EAS causes Cushing’s syndrome (CS) with significant morbidity and mortality. Early diagnosis and management of EAS is essential to ameliorate multiple symptoms and complications of CS. The purpose of this case report is to highlight challenges and difficulties in diagnosis and management of EAS. Case Presentation: A 72 year presented with progressive weight gain, proximal muscle weakness, shortness in breath on mild exertion and new onset of diabetes and persistent hypokalemia. Clinically she had signs and symptoms of CS. Laboratory tests and radiological imaging was in favor of EAS due to possible bronchial carcinoid. Confirmatory tests and surgery couldn’t be done due multiple acute complications and poor general health. On multidisciplinary team consensus decision she was treated with octreitide. She showed excellent sustained response to somatostatin analogue octreitide physically and biochemically. Conclusion: This rare case of high lights challenges of diagnosis and management of EAS in elderly lady with multiple acute comorbid conditions hindering full investigations to confirm diagnosis and surgical intervention.

Keywords: Cushing’s syndrome, Ectopic ACTH, Bronchial carcinoid, empty sella.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • EJPMR: AUGUST ISSUE PUBLISHED

    AUGUST Issue has been successfully launched on 1 August 2022.

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 August 2022 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database