EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANTIBACTERIAL ACTIVITY OF CARICA PAPAYA LEAF EXTRACTS ON SOME BACTERIA ISOLATED FROM WOUNDS OF PATIENTS ATTENDING THE JOS UNIVERSITY TEACHING HOSPITAL (JUTH)

Dafur Gayus Sale*, Dawurung Ayuba Bulus and Dafur Bala Sale

ABSTRACT

The antibacterial activity of the aqueous and methanolic leaf extracts of Carica papaya (pawpaw) was investigated using the agar diffusion method. The test organisms used were Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pyogenes. Gentamycin at concentration of 4 mg/ml was used as a standard drug (positive control) whereas distilled water was used as the negative control. The aqueous extract did not show antibacterial activity against any of the test organisms. The methanolic extract had antibacterial activity against Proteus mirabilis only, at concentrations of 700 mg/ml, 350 mg/ml and 175 mg/ml. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) values recorded were 87.5 mg/ml and 350 mg/ml respectively. Phytochemical screening showed the presence of alkaloids, tannins and steroids in the methanolic extract, whereas only carbohydrates and steroids were detected in the aqueous extract. Despite the insignificant activity of the extracts, these results suggest that Carica papaya leaves could still be used in the treatment of wound infections caused be Proteus mirabilis. It might be that the constituents of the leaves were greatly affected by the extraction procedures employed, hence the need for more investigations using other extraction methods.

Keywords: Antibacterial activity, Carica papaya, leaf extracts, bacteria, wounds, patients.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database