EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANTIBIOTIC RESISTANCE OF SALMONELLA AND SHIGELLA, ISOLATED FROM DIARRHEAL CHILDREN UNDER FIVE YEARS OLD AT THE NATIONAL HOSPITAL OF NIAMEY (NIGER)

Maman Illa*, Bouli Ali Diallo, Ousmane Sani, Issaka Bassira, Ousmane Abdoulaye, Adehossi Eric

ABSTRACT

Background: Infectious diarrhea is a real public health problem for the general population, especially infants and the immunocompromised. The establishment of microbiological surveillance is more than necessary. Materials and Methods: Samples from Diarrheal stools were collected and analyzed by standard bacteriology technique (microscopy, gram and slide microscopy, culture / identification, and serogrouping). The sensitivity of the strains to antibiotics was determined by the antibiogram technique. Detection and characterization of resistance genes was done by gene amplification using specific primers. Results: During the period from March to December 2016, the stools of 2181 children with acute diarrhea were collected for bacteriological examination. A sample of 316 of the consulting population was studied to isolate bacteria belonging to salmonella and shigella. 28 stools or 63.7% contained Salmonella and 16 or 36.3% contained Shigella. The study of antibiotic sensitivity showed high resistance rates in both shigella and salmonella: 100% against cyclins, 87.5%, cotrimoxazole, 56.25% amoxicillin, 56.25% amoxicillin- clavulanic acid, 68.75% chloramphenicol. On the other hand, a total sensitivity to imipenem, amikacin, gentamicin, ceftriazone, cefotaxime and ofloxacin, was observed in shigella. For Salmonella, resistance rates of 71.43%, 64.29%, 57.14%, 53.57%, 50%, respectively to amoxicillin, amoxicillin-clavulanic acid, trimethoprim-sulfamethoxazole and to tetracycline, were detected. But sensitivity to amikacin, nalidixic acid and imipenem is 100%. The study of the genetic support of these resistances made it possible to detect the tet, qnrS, qnrB, blaTEM, blaOXA, blaSHV genes. Conclusion:the study of antibiotic sensitivity revealed the emergence of resistance to 3rd generation cephalosporins and fluoroquinolones. The use of these molecules must therefore be done with caution in the treatment of shigellosis and salmonellosis.

Keywords: Antimicrobial resistance, Salmonella, Shigella, Niger.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database