STUDY OF THE INFLUENCE OF THE EFFECTS OF AN ALTERNATING MAGNETIC FIELD ON THE MORPHOLOGICAL PARAMETERS OF A TUMOR MODEL OF EXPERIMENTAL ANIMALS

*Sabirov D. R.

ABSTRACT

Aim of the study. To study the morphological features of the effect of exposure to an alternating magnetic field on a tumor model in the experiment. Material and methods. 10 white outbred rats were exposed to an alternating magnetic field - amplitude modulation of 350 kHz of medium frequency generated by a portable device "TOR" for 30 minutes for 7 days. Intact rats were taken as controls. Animals that were exposed to "TOR" and the control group were transplanted with a tumor strain of Walker. Results. Morphometric analysis of the organs of rats of the experimental group showed a decrease in the mass of the spleen (0.72 g) compared with normal animals (0.95 g). The mass of the liver of rats of the experimental group was 5.9 g. compared with 7.61g. in normal animals. Histologically, there were signs of a pronounced increase in lymphoproliferative activity and activation of intercellular connections. Conclusion. The presence of a pronounced antitumor effect was revealed - growth inhibition and tumor regression. Also, increased lymphoproliferative activity by 1.5 times, activation of intercellular connections. Thus, as a result of the studies, a number of quantitative characteristics of changes in the peripheral organs of the immune system were obtained during the antitumor effects of medium-intensity electromagnetic effects, carried out in accordance with the algorithms of activation therapy.

Keywords: medium frequency radio wave, immunity, tumor, tumor model, morphology, histology.