EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ETHANOL AND BENZENE INDUCED TOXICITY IN WISTAR RATS: AMELIORATIVE EFFECTS OF EXTRA-VIRGIN OLIVE OIL ON HAEMATOLOGICAL INDICES AND SPLEEN DAMAGE

Adetunji Opeyemi Adebola, Adetunji Oluwaseyi Adegoke, Adeoye Bayo Olufunso*, Adetunji Iyabode Toyin, Nwobi Nnenna Linda and Adeoye Ayodeji David

ABSTRACT

Background: The metabolic intermediates of benzene and ethanol are relatively poisonous to humans. Extra virgin olive oil (EVOO) is considered a natural source of bioactive compounds with beneficial effects on multiple organs. There is a dearth of empirical information on its protective roles in relieving symptoms associated with ethanol and/or benzene intoxication. Objective: This study was conducted to investigate the effects of extra virgin olive oil benzene and/or ethanol-induced haematological and splenic tissue aberrations in rats. Methodology: Forty-eight female Wistar rats (110kg-170kg) were randomly divided into 8 groups (n=6); Negative Control, EVOO= Extra Virgin Olive Oil, ETH= Ethanol, BEN= Benzene, ETH+BEN= Ethanol + Benzene, ETH+EVOO= Ethanol+ Extra Virgin Olive Oil, BEN+EVOO= Benzene+ Extra Virgin Olive Oil, ETH+BEN+EVOO= Ethanol+Benzene+ Extra Virgin Olive Oil. Animals were sacrificed and blood samples were collected for food blood count (FBC) analysis. Data were analyzed with a graph pad prism (version 5.03). p<0.5 was considered significant. The spleen was excised and processed for the histopathological assessment using Haematoxylin & Eosin (H&E) and Periodic Acid Schiff (PAS) staining techniques. Results: The FBC analysis showed alteration in macrophages, neutrophils and monocytes following treatment with ethanol and/or benzene, while also showing marked distortion of the histoarchitectural integrity of the splenic tissues. However, treatment with EVOO significantly (p<0.05) normalized haematological indices while also ameliorating splenic tissue distortions. Conclusion: Data obtained from this study revealed that extra virgin olive oil has anti-inflammatory potential on the Spleen.

Keywords: Extra Virgin Olive Oil, Benzene, Ethanol, Spleen, hematology.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database