EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DEVLOPMENT & CHARACTERIZATION OF FIMASARTAN TABLET USING UV SPECTROSCOPY

Rishabh Mittal*, Dr. Md. Semimul Akhtar and Dr. Nita Yadav

ABSTRACT

Fimasartan is the non-peptide angiotensine II receptor agonist which is utilised in the hypertension. A simple accurate & cost-effective approach is established for the estimation of Fimasartan tablet employing uv spectrophotometer in the API & bulk dose form. The Fimasartan exhibits λmax at 261 nm using 10% methanol solution. Fimasartan fulfilled Beer-Lambert’s law in the range of concentrations of 10-50μg/ml with pearson correlation (r2) of 0.999. The accuracy of the model was confirmed by percent recovery, by adding a known amount of the pure drug to the formulation and the percentage recovery was found to between 98.5 to 100.08% w/w, indicating that the developed method is accurate which indicates a good accuracy of the method and it shows that the method was free from the interference of excipients used in the formulation. The precision of the technique was provided in terms of the relative standard deviation and it should be evaluated by utilising a minimum of 6 determinations over 100 % concentration which reveals % RSD less than2 indicates that the procedure was exact. The limit of detection and quantification was determined to be 3 & 9.11 respectively. The percentage purity of the marketed formulation was found to be 97.18 % w/w. The suggested spectrophotometric approach was verified as per the ICH Q1A (R2) requirements.

Keywords: Fimasartan, UV spectrophotometry, linearity, method development, Validation.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database