FORMULATION AND EVALUATION OF CEFTRIAXONE TRANSDERMAL PATCH

Vakkanti Venkata Sridevi* Peddakhadar Shaik Mehraj, Patthi Himabindu, Reddapogu Sneha and Sheikh Sana

ABSTRACT

The ever increasing bacterial resistance is the motivation for the present work. Transdermal patch of ceftriaxone acts as a best alternative to oral administration to combat the rising bacterial resistance against antibiotics, reduce the risk of systemic side effects. A matrix type transdermal patch was developed containing ceftriaxone antibiotic as active pharmaceutical Ingredient. Different polymers and permeation enhancers like HPMC, PPG, and PEG-400 are used to formulate the patch. The compatibility of the drug and the polymers were studied by infrared spectroscopy which suggested absence of any incompatibility. Various parameters like drug content, thickness, folding endurance, % moisture content, % moisture gain, weight uniformity, drug content uniformity, invitro permeation were assessed for the prepared Transdermal films. The results obtained suggested that F4 formulation showed better physico-chemical properties and drug release compared to other formulations. It also showed excellent antimicrobial properties against Gram Negative (E.Coli) and Gram positive (Staphylococcus aureus) Bacteria.

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