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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Mulchand Shende*, Yogesh Gavhane and Pradeep Mundkar


Carbamazepine (CBZ) belongs to BCS Class-II used to control some types of seizures in the treatment of epilepsy and neuropathic pain by blocking use-dependent sodium channels. The main objective of research work was to the suitable enhancing solubility of carbamazepine for oral administration of capsules. The lyophilized of CBZ were prepared employing different concentrations of polaxamer 407 and skimmed milk powder in different combinations as a carriers by lyophilization solid dispersion technique using 32 factorial design. CBZ was compatible with both the polymers and it was confirmed by FTIR and DSC study. Total nine formulations were designed and are evaluated for physicochemical properties, differential scanning calorimetry, X-Ray powder diffractometry, water content, saturation solubility, compressibility and fluidity, assay, and in-vitro drug release. All of lyophilized batches showed 1.84 to 4.94 times increase in saturation solubility. Its amorphous nature was confirmed from reducing melting point with low ΔH in DSC and minimizing of RDC in XRD. Polynomial equations were developed for saturation solubility, in-vitro drug release and validity were verified by designing 2 check point formulations. The maximum drug release was observed for batch F9 (93.98±1.90%) than pure CBZ (28.38±0.10%) after 80 min. This might be due increase in wettability and decrease in crystallinity of CBZ particles with hydrophilic polymers. Formulated solid dispersions showed improvement in flow properties and compressibility of CBZ. All the batches were stable in normal temperature and humidity conditions in the form of drug contents. There were no any color changes which revealed stability of CBZ.

Keywords: Carbamazepine; amorphous solid dispersions; oral administration; lyophilization technique.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia