EVALUATION OF ANTHELMINTIC PROPERTY OF CARICA PAPAYA SEEDS

*Rahul Jodh, Mukund Tawar, Kiran Gomkale, Pradyumna Keche, Vedant Radke, Rhushikesh Kadu

ABSTRACT

Background: For inflicting life-threatening infection in humans and different live stalks, the simplest action for controlling the calamitous situation is to apply potent anthelminthic remedy, but there are few anthelminthic medications on the market and those which might be to be had create resistance in the course of remedy in most of the species of helminths. Consequently, we are going to evaluate the anthelminthic assets of Carica Papaya seeds for regulating the life- threatening infection in humans and different live stalk. Methods: The seeds of Carica Papaya were kept for extraction, and the hot maceration method was adapted for extraction. The obtained extract was subjected to phytochemical screening and the tests for alkaloids, saponins, tannins, anthraquinone glycosides, reducing sugar for glycosides, and flavonoids were carried out by standard procedure. For the in vitro anthelminthic study, suspension of our crude extract was prepared at a dose of 200 mg/ml by using HPMC as a thickening agent, and for standard, albendazole was used. Phertima posthuma was used for anthelminthic studies because of its anatomical and physiological uniformity with the roundworms which are present in the intestine. The seeds of Carica Papaya were kept for extraction, and the hot maceration method was adapted for extraction. Results: Out of the seven samples of different concentration ratios, we got a 99% yield from the sample of pure water (powder), 82% from the sample of 70:30 HA and 0% from the sample of pure ethanol. Phytochemical screening was carried out by standard procedure. We found alkaloids, tannins, saponins, reducing sugars of glycosides, and flavonoids in our crude extract, and we got a negative result for anthraquinone. The sample of pure water (powder) shows the least time of paralysis and death, and as compared to reference standard albendazole, it shows only a difference of 12 sec for paralysis and 20 sec for the death of worms. Conclusion: As the average time of paralysis and death for extract of pure water (powder) was minimum as compared to other extracts and as compared to albendazole, it showed a difference of 12 secs for paralysis and 20 secs for the death of earthworms so we concluded that our evaluation was successful.

Keywords: Carica Papaya, Phertima Postuma, Albendazole, Pure Water, Anthelminthic, Helminth.