EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

TO DESIGN AND EVALUATE A CHRONOMODULATED PRESS COATED TABLET OF A PRO DRUG

Fasi Ahmed Mohd*, Dr. Pawan Kumar, Dr. R. Sridhar Babu Dr. Shaik Mohammed Khasim, Abdul Sayeed

ABSTRACT

The aim of the present study was to formulate and evaluate pulsatile drug delivery system of Albuterol based on chrono pharmaceutical approach for the treatment of asthma. Pulsatile drug delivery systems were prepared by the press coated method. The pre-compression parameters of all formulations showed good flow properties and these can be used for tablet manufacture. The post-compression parameters of all formulations were determined and the values were found to be satisfactory. So Finally Based on All Parameters P3F8 was optimized from the press coated technique based upon its lag time and the cumulative percentage drug release. The press coated techniques showed the delayed release pattern in a very customized manner. As further into the study formulations showed satisfactory result in the DSC study. From DSC graphs it is evident that the polymorphic nature of the drug is intact. Pharmacokinetic study was performed to understand the bioaviability of the drug and to understand the lag time in optimized formulations. From the animal studies performed in the rabbits, formulations have shown phenomenal increase in the AUC when compared to that of the Marketed Formulation (Asthalin) i.e 5940.99 ng.mg/ml and 11119.05 ng.mg/ml for marketed formulation and press coated formulation.

Keywords: Pulsatile drug delivery, Albuterol, presscoated.


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