EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

TO DESIGN AND EVALUATE A CHRONOMODULATED PRESS COATED TABLET OF A PRO DRUG

Fasi Ahmed Mohd*, Dr. Pawan Kumar, Dr. R. Sridhar Babu Dr. Shaik Mohammed Khasim, Abdul Sayeed

ABSTRACT

The aim of the present study was to formulate and evaluate pulsatile drug delivery system of Albuterol based on chrono pharmaceutical approach for the treatment of asthma. Pulsatile drug delivery systems were prepared by the press coated method. The pre-compression parameters of all formulations showed good flow properties and these can be used for tablet manufacture. The post-compression parameters of all formulations were determined and the values were found to be satisfactory. So Finally Based on All Parameters P3F8 was optimized from the press coated technique based upon its lag time and the cumulative percentage drug release. The press coated techniques showed the delayed release pattern in a very customized manner. As further into the study formulations showed satisfactory result in the DSC study. From DSC graphs it is evident that the polymorphic nature of the drug is intact. Pharmacokinetic study was performed to understand the bioaviability of the drug and to understand the lag time in optimized formulations. From the animal studies performed in the rabbits, formulations have shown phenomenal increase in the AUC when compared to that of the Marketed Formulation (Asthalin) i.e 5940.99 ng.mg/ml and 11119.05 ng.mg/ml for marketed formulation and press coated formulation.

Keywords: Pulsatile drug delivery, Albuterol, presscoated.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • EJPMR: AUGUST ISSUE PUBLISHED

    AUGUST Issue has been successfully launched on 1 August 2022.

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 August 2022 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database