DEVELOPMENT AND CHARACTERSATION OF FAST DISSOLVING TABLETS OF LAFUTIDINE BY USING NATURAL SUPER DISINTIGRANT
Praveen V. Vijapur*, Avinash S. Gudigennavar, Anita R. Desai, Laxman S. Vijapur, Sushmita D. Utagi and Shivagond M. Nemagoud
The Fast dissolving tablets of Lafutidine have been organized via way of means of direct compression approach. The drug solubility become better by means of solid dispersion strategies like Melt evaporation approach and solvent evaporation approach. The characterization of the organized strong dispersions become finished. The mucilage extracted from the dehydrated Banana powder and Plantago ovata seeds become used as natural super disintegrant. The physicochemical parameters like pre-compression and post compression assessment have been accomplished as in step with pharmacopoeia requirements and compatibility. The FTIR spectral evaluation confirmed that there has been no drug interplay with formulations components of the tablet as there may be no variation and shift in bands, it could be justified there may be no interplay among drug and polymer. The Solid dispersion with 1:3 ratio suggests higher aqueous solubility and is the reason higher dissolution price of the drug. Pre compression parameters confirmed top glide properties. And Post compression parameters like thickness, hardness, weight-version, friability, wetting-time, water absorption ratio, disintegration time, drug content, in-vitro drug release take a look at proven top consequences. Formulation F2 confirmed desirable outcomes throught the take a look at. From the consequences, it become concluded that the FDTs of Lafutidine containing Dehydrated banana powder with the Solid dispersion Cross caramallose sodium are confirmed much less disintegration time and in-vitro drug release take a look at is quicker than the Solid dispersion of drug with the PEG 4000.
Keywords: Fast dissolving tablets (FDTs), Lafutidine, Dehydtrated banana powder (DBP) and Plantago ovata mucilage (POM).
[Full Text Article]