EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DEVELOPMENT AND CHARACTERSATION OF FAST DISSOLVING TABLETS OF LAFUTIDINE BY USING NATURAL SUPER DISINTIGRANT

Praveen V. Vijapur*, Avinash S. Gudigennavar, Anita R. Desai, Laxman S. Vijapur, Sushmita D. Utagi and Shivagond M. Nemagoud

ABSTRACT

The Fast dissolving tablets of Lafutidine have been organized via way of means of direct compression approach. The drug solubility become better by means of solid dispersion strategies like Melt evaporation approach and solvent evaporation approach. The characterization of the organized strong dispersions become finished. The mucilage extracted from the dehydrated Banana powder and Plantago ovata seeds become used as natural super disintegrant. The physicochemical parameters like pre-compression and post compression assessment have been accomplished as in step with pharmacopoeia requirements and compatibility. The FTIR spectral evaluation confirmed that there has been no drug interplay with formulations components of the tablet as there may be no variation and shift in bands, it could be justified there may be no interplay among drug and polymer. The Solid dispersion with 1:3 ratio suggests higher aqueous solubility and is the reason higher dissolution price of the drug. Pre compression parameters confirmed top glide properties. And Post compression parameters like thickness, hardness, weight-version, friability, wetting-time, water absorption ratio, disintegration time, drug content, in-vitro drug release take a look at proven top consequences. Formulation F2 confirmed desirable outcomes throught the take a look at. From the consequences, it become concluded that the FDTs of Lafutidine containing Dehydrated banana powder with the Solid dispersion Cross caramallose sodium are confirmed much less disintegration time and in-vitro drug release take a look at is quicker than the Solid dispersion of drug with the PEG 4000.

Keywords: Fast dissolving tablets (FDTs), Lafutidine, Dehydtrated banana powder (DBP) and Plantago ovata mucilage (POM).


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database