REVIEW ON OCULAR INSERTS: AN EVOLUTIONARY TREND FOR TARGETED DRUG DELIVERY
Kazi Wasim B., Khadkutkar Vijayananda K.* and Sanjay S. Dudhamal
ABSTRACT
The eye is a sensory organ. It is difficult to study from a drug delivery point of view. An ocular insert is a novel approach for drug delivery into the eye it is an advanced technology in eye disease therapy. The most frequently used and easy to administer dosage form available is eye drops. Conventional ocular drug delivery has major disadvantages like fast precorneal loss which could be overcome by a novel approach like an ocular insert. In ocular inserts, the films are prepared and are directly placed in a cul-de-sac of the eye. Ocular inserts are defined as preparations with a solid or semisolid consistency, whose size and shape are specially designed for ophthalmic application. Treating ocular diseases require localized administration of the drug in the eye. In recent years, there has been using of polymer-based delivery is very popular. Utilization of the principle of controlled release by means of the ocular insert with the help of polymers offers an attractive approach to the problem of prolonging precorneal drug residence time. This review article discusses the anatomy of the eye, ocular insert as a novel dosage form and emphasizes on advantages of ocular insert, classification, and various methods available for formulating ocular insert and also evaluation parameters.
Keywords: Eye, Films of preparation, Novel dosage form, Ocular insert.
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