MATRIX TABLETS AS ORAL SUSTAINED RELEASE DOSAGE FORMS: AN OVERVIEW
*Priyanka, Jayesh Dwivedi, Ayush Garg
Oral route of drug administration is oldest and safest mode of drug administration. It posses several advantage. It does not pose the sterility problem and minimal risk of damage at the site of administration. It provides accurate dosing without assistantship of administration. In conventional oral drug delivery system, there is little or no control over release of drug, and effective concentration at the target site can be achieved by administration of grossly excessive dosage form. This kind of dosing pattern result in constantly changing, unpredictable and often sub or supra therapeutic plasma concentration, leading to marked side effects in some cases. Moreover, the rate and extent of absorption from conventional formulation may vary greatly, depending on factor such as physiochemical properties of drug, presence of excipients, various physiological factors such as presence or absence of food, pH of gastrointestinal tract, G.I. motility etc. These problems can be minimized by oral controlled drug delivery systems.
Keywords: Drug release, drug delivery system, controlled drug delivery, sustained release, matrix tablets.
[Full Text Article]