A REVIEW: NOVEL IN- SITU GEL APPROACHES FOR DRUG DELIVERY SYSTEM

Ruchi Verma*, Pratima Katiyar, Dr. Kalpana Kushwaha, Vandana Yadav, Sonam Sharma

ABSTRACT

The 'in-situ gel' system has emerged as one of the most creative drug delivery technologies, thanks to its unique ‘sol to gel' transition, which aids in the continuous and regulated release of medications. Before entering the body, a formulation is in solution form, but under certain physiological conditions, it transforms into a gel form. This is referred to as an in-situ gelling mechanism. In situ gel formation is applied to a range of polymers, which could be used for some drug administration routes. The in-situ gelling method has a wide range of applications and benefits in today's society. The purpose of this work is to provide an overview of in situ gels, including their mechanism, the numerous polymers used, and their applications.

Keywords: In-situ gel, Polymers, oral disease.