REVIEW - SOLID DISPERSION: PROMISING WAY OF BOOSTING THE DRUG'S SOLUBILITY AND BIOAVAILABILITY
Mali Kamlesh D.*, Bhansali Saurabh V., Bagad Rutuja B., Bhave Rucha M., Bag Monali R. and Barhate Kunal R.
ABSTRACT
Formulation scientists facing a challenges in case of Improving oral bioavailability of drugs those given as solid dosage forms due to solubility problems. Many techniques have been exercised to improves solubility and oral bioavailability of drugs. Among several methods, Solid dispersion is a solubilization technology emphasizing basically on drug-polymer two component systems in which drug dispersion and its stabilization is the key for formulation development. Different formulation strategies have been taken to prepare solid dispersions. It is evident that solid dispersions improve solubility of drug particles thus enhancing dissolution characteristics of drugs they increase the oral bioavailability. This review paper will focus on solubility and its mechanism, factor affecting solubility, approaches of solubility enhancement, different aspects of solid dispersion preparation; their classification, preparation method, and characterization technique.
Keywords: Bioavailability, Solubility, Biopharmaceutical classification, solid dispersions, solid dispersions method, characterization.
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