EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

NURITIONAL STATUS OF CANCER PATIENTS ATTENDING CLINICS IN NNAMDI AZIKIWE UNIVERSITY TEACHING HOSPITAL, NNEWI, ANAMBRA STATE. SOUTHEAST NIGERIA

Ogbu I.S.I*, Ugwu M.C., Ukibe N.R., Mbachu N.A, Ogbu C.C., Nwobodo E.I and Ibe C.O.C

ABSTRACT

Malnutrition leads to immune impairment and worsens the effect of cancer. This study assessed nutritional status of cancer patients in a tertiary Hospital clinics in Anambra State Nigeria. Fifty (50) cancer patients (25 drug naïve and 25 on drug treatment) and 25 apparently healthy controls were recruited for the study. Clinical status of the patients was obtained from Hospital records. A questionnaire and subjective global nutritional assessment (SGNA) form were used to obtain anthropometric and nutritional status of the subjects. Serum proteins, and haemoglobin were assayed spectrophotometrically while elements were assayed using AAS. CD4+ count of the patients was done by flow cytometer. The results showed body mass index, BMI (19.78±1.67kg/m2), MUAC, (1.70m2 ±0.21 m), albumin (1.86±0.13g/dl), Hb (10.52±1.62g/dl), iron (0.65±0.0.10ppm), zinc (0.69±0.14ppm) and selenium (0.54±0.08ppm) of drug naïve patients were significantly lower than those of on-treatment group; BMI-(22.05±1.61kg/m2), MUAC, (1.93m2 ±0.15 m),albumin (2.50±0.36g/dl), Hb (12.01±1.02g/dl), serum iron (0.91±0.16ppm), zinc (1.08±0.13ppm), and selenium (0.63±0.08ppm) and control group; BMI –(24.77±2.59kg/m2), MUAC, (2.54m2 ±0.60 m), albumin – (3.44±0.36g/dl), Hb – (13.80±1.23g/dl), iron – (1.18±0.14ppm), zinc – (1.18±0.15ppm), selenium – (1.06±0.14ppm), (p = 0.00). These parameters of the on-treatment group were also significantly lower than those of the control group (p = 0.00). However, total protein (9.14±1.42g/dl), and copper (1.32±0.19ppm) of the drug naïve patients were not significantly higher than on-treatment (8.72±1.66g/dl, 1.21±0.16ppm), (p > 0.05) but differed significantly with the control groups (7.05±0.84g/dl, 0.77±0.09ppm), (p = 0.00). Those of the on-treatment group were also higher than the control (p – 0.00).Subjective Global Assessment index showed that 53% and 60% respectively of the drug naïve and on-treatment cancer patients were undernourished. Cancer patients studied were undernourished and this can hinder effective management. Adequate nutrition deserves even greater attention in the management of cancer patient especially in economically poor setting.

Keywords: “Nutrition”, “nutritional status”, “malnutrition”, “Cancers”, “trace elements”.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database