EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

HYPOLIPIDEMIC AND PLASMA PROTEINS STABILIZING EFFECT OF GONGRONEMA LATIFOLIUM IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Gabriel Otu Ujong*, Justin Atiang Beshel, Nkanu Etah Etah, Idara Asuquo Okon and Daniel Udofia Owu

ABSTRACT

Objectives: Gongronema latifolium (GL) is a medical plant with myriad healing potentials. But it’s effect on serum lipids and proteins in diabetic condition has net been elucidated. This work was therefore designed to evaluate the effect of ethanolic leaf extract of Gongronema latifolium on lipid profile and plasma proteins in Streptozotocin-induced diabetic rats. Methods: A total of 40 Wistar rats of both sexes initially weighing between 150g-200g were divided into five (5) groups of eight (8) rats each. Group 1 was the normal control (administered normal saline placebo orally). Group 2 received 200mg/kg GL orally. Group 3 was the diabetic group administered 65mg/kg of streptozotocin (STZ) intraperitoneally for two days with an interval of one day in between, their blood was collected via the tail vein for glucose determination using a portable glucometer. Group 4 was the diabetic + 200mg/kg GL group. Group 5 was the diabetic + insulin (subcutaneously). The feeding regimens lasted 28 days. Blood samples were collected via cardiac puncture. Results: There was a significant (p<0.05) increase in the glucose level of the diabetic group compared to the control. Intervention with GL and insulin significantly reduced the glucose level towards normal. High density lipoprotein was significantly (p<0.01) decreased in the diabetic group with a corresponding increase in total cholesterol, low density lipoprotein, triglycerides, and very low lipoprotein. Treatment with GL and insulin reversed the changes towards normal. There is also a decrease in total serum protein in Gongronema latifolium treated group when compared with the insulin treated group, also a corresponding significant decrease in globulin and albumin level in the GL+DM treated group compared with the diabetic group. Conclusion: Gongronema latifolium leaf extract has an hypolipidemic potential and also stabilizes plasma proteins levels in diabetic condition and target organ.

Keywords: Gongronema Latifolium, Diabetes Mellitus, serum lipids, Proteins, STZ, insulin.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database