EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

SERUM CALPROTECTIN AND CRP: A POSITIVE PROGNOSTIC DETERMINANT IN NEWLY DIAGNOSED PRIMARY HYPERTENSION

*Dr. Kanwal, Dr. Vishal, Dr. FNU Sahrish, Dr. Sumeet Kumar, Dr. Meena Kumari, Dr. Berkha, Dr. Vijay

ABSTRACT

Background: The most common cause of cardiovascular death is hypertension. Endothelial damage and inflammation are two hallmarks of the illness, which is still not completely understood. Systemic inflammatory disorders, infection, and atherosclerosis all increase the level of calprotectin in the bloodstream. Aim: Serum calprotectin levels were measured to assess inflammation in individuals with newly diagnosed primary hypertension. Design: Cross sectional study. Methodology: A cross-sectional study was conducted involving fifty newly diagnosed hypertensive patients and fifty healthy adults after following inclusion criterion. Each patient's blood pressure, metabolic data, and demographic information were collected. Calprotectin levels in the blood were measured using an ELISA KIT. Assessment of the variables that influence serum calprotectin levels as well as the risk factors for hypertension was performed. Analysis was performed using SPSS version 25. A Chi-square test with a significance level of less than or equal to 0.05 was carried out. Results: Out of 100 patients enrolled, the difference between the control group's serum calprotectin levels of 239.8 ng/mL and the hypertensive patient group's levels of 97.6 ng/mL was statistically significant. The control group's levels were higher. (p =0.001). There is no association between serum calprotectin levels and age, gender, or BMI in the group of people who have hypertension. A decreased blood calprotectin level was shown to be independently associated to mean systolic blood pressure (r value=-.485**) (p = 0.001). Serum calprotectin at 131.9 ng/mL differentiated hypertensives from healthy controls with 71.2% sensitivity and 81.1% specificity. (AUC= 0.767). Conclusion: The findings of this investigation contradicted our hypothesis that an elevated calprotectin level in newly diagnosed hypertension individuals indicates inflammatory processes at the cellular level. Studies on individuals at varying stages of hypertension may provide light on the association between hypertension and calprotectin. Calprotectin's role in hypertension-related inflammation is a complicated one, and molecular research is needed to comprehend it.

Keywords: Primary hypertension, Calprotectin, inflammation.


[Full Text Article] [Download Certificate]

Citation

  All Since 2019
 Citation  3086  2560
 h-index  18  17
 i10-index  64  44

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 December 2024 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

  • EJPMR: DECEMBER ISSUE PUBLISHED

    DECEMBER 2024 issue has been successfully launched on DECEMBER 2024.

  • EJPMR New Impact Factor

    EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along witcertificate to promote resear activity of scholar.

Best Article of current issue :

Dr. Kartik Neog
Download Article : Click here