EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

SERUM CALPROTECTIN AND CRP: A POSITIVE PROGNOSTIC DETERMINANT IN NEWLY DIAGNOSED PRIMARY HYPERTENSION

*Dr. Kanwal, Dr. Vishal, Dr. FNU Sahrish, Dr. Sumeet Kumar, Dr. Meena Kumari, Dr. Berkha, Dr. Vijay

ABSTRACT

Background: The most common cause of cardiovascular death is hypertension. Endothelial damage and inflammation are two hallmarks of the illness, which is still not completely understood. Systemic inflammatory disorders, infection, and atherosclerosis all increase the level of calprotectin in the bloodstream. Aim: Serum calprotectin levels were measured to assess inflammation in individuals with newly diagnosed primary hypertension. Design: Cross sectional study. Methodology: A cross-sectional study was conducted involving fifty newly diagnosed hypertensive patients and fifty healthy adults after following inclusion criterion. Each patient's blood pressure, metabolic data, and demographic information were collected. Calprotectin levels in the blood were measured using an ELISA KIT. Assessment of the variables that influence serum calprotectin levels as well as the risk factors for hypertension was performed. Analysis was performed using SPSS version 25. A Chi-square test with a significance level of less than or equal to 0.05 was carried out. Results: Out of 100 patients enrolled, the difference between the control group's serum calprotectin levels of 239.8 ng/mL and the hypertensive patient group's levels of 97.6 ng/mL was statistically significant. The control group's levels were higher. (p =0.001). There is no association between serum calprotectin levels and age, gender, or BMI in the group of people who have hypertension. A decreased blood calprotectin level was shown to be independently associated to mean systolic blood pressure (r value=-.485**) (p = 0.001). Serum calprotectin at 131.9 ng/mL differentiated hypertensives from healthy controls with 71.2% sensitivity and 81.1% specificity. (AUC= 0.767). Conclusion: The findings of this investigation contradicted our hypothesis that an elevated calprotectin level in newly diagnosed hypertension individuals indicates inflammatory processes at the cellular level. Studies on individuals at varying stages of hypertension may provide light on the association between hypertension and calprotectin. Calprotectin's role in hypertension-related inflammation is a complicated one, and molecular research is needed to comprehend it.

Keywords: Primary hypertension, Calprotectin, inflammation.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database