CROSS-SECTIONAL ANALYSIS OF LEUKEMIA IN RELATION TO ABNORMAL BLOOD COUNTS OF PATIENTS AND THEIR ASSOCIATED FACTORS IN NIMRA HOSPITAL, LUMHS

Dr. Vishal*, Dr. Kanwal, Dr. Meena Kumari, Dr. FNU Sahrish, Dr. Berkha and Dr. Sumeet

ABSTRACT

Background: The heterogeneous category of leukemia, which is the top ten most prevalent causes of cancer mortality and morbidity worldwide, comprised of many diverse and physiologically distinct subtypes. There is a scarcity of information in our area, particularly in the research zone, about the prevalence of leukemia and its risk factors. Aim: This research aims to estimate leukemia prevalence among individuals with abnormal hematological parameters in Nimra Medicine ward, Lumhs. Study Design: Cross sectional study. Methodology: 414 individuals with aberrant hematological parameters were studied cross-sectionally. Sysmex autohematology analyzer created venous blood CBC. Each patient had peripheral blood morphology and bone marrow aspiration. SPSS version 25 examined the collected data. P0.05 was considered significant for Chi square. Results: Out of 414 participants, prevalence of leukemia was found as 53 i.e; 12.8%, while acute myeloid Leukemia (20 i.e. 4.83%), Acute Lymphoid Leukemia (16 i.e. 3.86%), Chronic Myeloid Leukemia (12 i.e. 2.89%), Chronic Lymphoid Leukemia(3 i.e. 0.72%), Myelodysplastic Syndrome, (01 i.e. 0.241% ) and undifferentiated leukemia comprises (01 i.e. 0.241%) respectively. AML is related with older age (p=0.001), being male (p=0.017), anemia (p=0.013), and rural location (p=0.017). Data was processed using SPSS 26.0. P0.05 was crucial for Chi square. Leukemia is common among people with aberrant blood counts, prompting more extensive research of important factors and predictors utilising modern diagnostic methods.

Keywords: Leukemia, blood counts, myeloid, lymphoid, ALL; AML; CML; CLL;