EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EVALUATION OF LIPID PARAMETERS IN PATIENTS WITH DIABETES MELLITUS AND ISCHEMIC HEART DISEASE

Juhi Kataria*, Gurpreet Kaur Gill, Ravi Kumar Dhawan

ABSTRACT

Diabetes mellitus is a chronic condition that occurs when the body cannot produce sufficient insulin, caused by a genetic predisposition along with environmental factors. The number of people with diabetes mellitus worldwide is increasing and by 2035 this will have risen to 552 million. Patients with type 2 diabetes mellitus have a considerably higher risk of cardiovascular morbidity and mortality, as compared to non-diabetics. And this risk is associated with hypertension, dyslipidemia and obesity in these patients. Thus it is imperative to evaluate the biochemical parameters, most importantly lipids. The objective of the present study was to evaluate the lipid profile in patients with diabetes mellitus and ischemic heart disease and its comparison with healthy controls. One hundred and twenty individuals participated in this study and were categorized on the basis of health (diabetic with ischemic heart and non diabetic) and gender (males and females). Exclusion criteria were subjects with the history of alcoholism, smoking, renal diseases, thyroid disorders and pregnancy. All the individuals were subjected to detailed history, biochemical analysis for fasting blood sugar, total cholesterol, triglycerides, low density lipoprotein (LDLc), high density lipoprotein (HDLc), very low density lipoprotein (VLDLc). Both males and females showed significant increase in total cholesterol, triglycerides, LDLc and VLDLc, as compared to healthy controls. However, both males and females showed low levels of HDLc as compared to healthy controls. The protective function of HDLc may be lost in type 2 diabetics leading to protein modifications, resulting in oxidative stress. Females were found to depict higher levels of total cholesterol, LDLc and TC:HDLc, as compared to males. This study showed that females are prone to diabetic dyslipidemia. This can be reduced by controlling diabetic induced lipid abnormalities in patients through different approaches and also enable us to maintain the health of patients by detecting heart disease at an early stage and its prevention with appropriate medications.

Keywords: Diabetes mellitus, cardiovascular disease, dyslipidemia, cholesterol, triglycerides, high density lipoprotein.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database