COMPARATIVE STUDY ON COMBINED EFFECT OF TREADMILL EXERCISE TEST AND HYPOTHYROIDISM ON OXIDATIVE STRESS OF SUB-CLINICAL AND OVERT HYPOTHYROIDISM PATIENTS

*Dr. Dilnawaz Ahmed, Dr. Surajit Kumar Mukhopadhyay and Dr. Srila Ghosh Chowdhury

ABSTRACT

Background: The present study was conducted on patients suffering from subclinical and over hypothyroidism and healthy controls. Materials and methods: The sample size was calculated to be 100 (50 cases and 50 healthy controls). They were recruited from the outpatient department with history of overt or subclinical hypothyroidism with no clinical evidence of CAD. Thyroid related parameters (FT4 and TSH) and cardiac parameters (SBP, DBP, PR, ECG HR, QRS) and oxidative stress biomarker (pre-TET MDA and post-TET MDA) were measures and correlated. Results: The mean FT4 was 0.80±0.23 in the case group and 0.75±0.30 in the control group. The TSH was 13.32±9.71 in the case group and 3.19±4.26 in the control group. The pre-TET MDA was 18.74±6.56 in the case group and 3.30±0.72 in the control group. The post-TET MDA was 20.62±6.56 in the case group and 5.45±0.89 in the control group. Statistically significant difference exists between the groups (p value≤0.05). Conclusion: The present study shows that there is a positive correlation between FT4 and post- TET MDA and a positive correlation between TSH and post-TET MDA. That means, oxidative stress as well as MDA levels will increase if there is any increase in the FT4 level and TSH level.

Keywords: Sub-clinical hypothyroidism, overt hypothyroidism, treadmill exercise test, FT4, TSH.