( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Dr. Ketki Jandial* and Dr. Mamta Gupta


Background: Propofol is an ideal anesthetic agent but the incidence of pain on the intravenous injection of propofol is 30-90%.The immediate pain is due to irritation of the veins and delayed pain may be due to kinin release. Colloids, such as Hyroxyethyl Starch (HES) are used for intra-operative fluid therapy in anaesthesia and are considered to be safe. The aim of this study was to compare the incidence and severity of pain on propofol injection in patients pre-administered either HES 130/0.4 or 0.9% normal saline (NS) bolus during induction of anaesthesia. Method: A prospective randomized placebo-control double-blind study was carried out in the Department of Anesthesia, Government Medical College, Jammu, over a period of 6 months. A total of 100 patients, 18-65years old, of either gender, undergoing elective surgery under general anaesthesia, were recruited, with 50 each in two groups: one received 100ml of 6% hydroxyethyl starch (HES) 3 to 5 min before propofol injection, and the other received Normal Saline. Results: Both groups were comparable with respect to age, gender, weight and height. None of the patients were lost to follow up. Incidence of pain on injection was significantly lower in group I (14, 28.0%). There were no significant differences in mean arterial pressure and heart rate between the two groups. The effect size for pain between the groups was large (0.73). Conclusion: Pre-administration of 6% HES (130/0.4), 3 to 5 min before propofol injection, significantly decreased the pain on injection with propofol.

Keywords: Adult, adverse effects, injections, pain, propofol.

[Full Text Article]



  • New Issue Published

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    SEPTEMBER issue has been successfully launched on 1 SEPTEMBER 2023.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database