ASSESSING THE EFFICACY AND SAFETY OF A TREATMENT REGIMEN COMPRISING ASPIRIN, PROMETHAZINE, AND MULTIVITAMIN COMBINATION FOR MILD TO MODERATE SYMPTOMATIC SUBJECTS OF COVID 19: A RANDOMIZED CONTROLLED TRIAL

Dr. Vidyadhar G. Vaidya*, Mr. Rohit Shelatkar, Dr. Atul Vadgaonkar, Dr. G. Sunil Kumar, Dr. Srilata Purunaik, Dr. Gayatri Ganu and Dr. Shashank Joshi

ABSTRACT

Introduction: The COVID-19 pandemic with the emergence of numerous variants is concomitant with high morbidity and mortality. To assess the efficacy and safety of treatment regimen comprising aspirin, promethazine, and multivitamin combination for mild to moderate symptomatic subjects of COVID-19. Trial design: A randomized controlled clinical trial was conducted using an interventional drug regimen, APMV2020, comprising two tablets A: a combination of aspirin and promethazine, B: multivitamins and trace elements, on 60 COVID-19 positive subjects. Methodology: The subjects were randomized to receive either the control intervention (clinical management protocol for COVID-19 advocated by the Indian Council of Medical Research (ICMR), Ministry of Health and Family Welfare, Government of India) or the test intervention (Treatment with APMV2020 tablets along with the standard control treatment. The assessment days were baseline, day 5 and 10. Results: APMV2020 significantly (<0.05) improved symptoms of COVID-19 like cough, breathlessness and fatigue, myalgia, headache, diarrhea, anosmia as compared to the control group. APMV2020 treatment also reduced inflammatory markers like LDH, ferritin and CRP. Conclusion: The APMV2020 treatment for COVID-19 provides better and faster clinical recovery of subjects suffering from COVID-19 symptoms, besides averting the possible disease progression. This may be the promising approach to recover patients of COVID-19.

Keywords: Aspirin, Vitamin C, promethazine, zinc, selenium, vitamin D, COVID-19.