SOME RESULTS OF EXPERIMENTAL RESEARCHES DEVOTED TO THE STUDY OF ALTERNATING MAGNETIC FIELD EXPOSURE EFFECTS ON TUMOR MODELS

Sabirov D. R.*

ABSTRACT

The aim of the study. There was a presentation of the results of the work done on the study of the effects of exposure to an alternating magnetic field generated by the therapeutic apparatus "TOR" on the hematological parameters of experimental animals with an induced tumor model. Material and Methods. Used 200 experimental animals (100 outbred rats and 100 outbred mice). The research was carried out thanks to the use of a portable device "TOR", which is a biostimulator that generates electromagnetic radiation. To accomplish the tasks, outbred rats were divided into 4 groups, of which the tumor strain "Walker's sarcoma" was transplanted into the animals. The first group is presented - rats with a developed tumor process against the background of exposure to the waves of the "TOR" apparatus for 5 days, which we called the experimental group; the second group consisted of rats with a developed tumor process without exposure to the waves of the TOR device; the third group consisted of intact rats against the background of exposure to the waves of the apparatus "TOR" for 5 days and the fourth group consisted of intact rats. Conducted hematological studies. Results. The analysis showed that radio waves do not cause massive cell death, but apoptosis of transformed cells and proliferation of immunocompetent cells are induced. Inhibition of tumor growth by volume was 45.2%, by weight - 31.7% when comparing the experimental and intact (without exposure to TOR) groups of rats with an implanted Walker tumor. Shown in the experimental group basophilia, eosinophilia, neutropenia and lymphopenia. After exposure to an alternating magnetic field, slight monocytosis, neutrophilia and lymphocytes are normal. The number of immunocompetent cells increased and there was a 2-fold increase in neutrophil activity compared to the data before and without exposure to an alternating magnetic field, as well as an increase in the phagocytic potential and functional heterogeneity of granulocytes. Effector leukocytes were also increased 2.1 times. Conclusion. The possibility of exposure to electromagnetic radio waves for the purposes of clinical oncology remains one of the urgent tasks of medicine. The versatility of the effect of electromagnetic fields on an organism with a tumor is realized due to various mechanisms of interaction with biological structures at all levels of organization and is largely due to their influence on molecular processes and other functions in the tumor cell.

Keywords: medium frequency radio wave, hematology, tumor, immunity, cancer process, magnetic field.