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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Sanmi Tunde Ogunsanya, Olugbenga Ayodeji Ayannuga, Adegbenga Rotimi Owolabi, Taiwo Olusola Osibogun and Ayodeji Zabdiel Abijo*


Introduction: Temporal lobe epilepsy (TLE) the most common form of drug-refractory epilepsy in humans. This study evaluated the histomorphology of the neocortex, subcortical white matter and the timeline dynamics of the above parameters at different epileptogenesis phases following lithium-pilocarpine-induced TLE in Wistar rats. Methods: Sixty Wistar rats were assigned into 3 groups A-C (n=20each). A, B and C; acute, latent and chronic groups. Each group had 3 sub-groups {Control (5), sham (5) and experimental (10)}. Control and sham received 2mL/kg normal saline and diazepam (10mg/kg) intraperitoneally respectively. Experimental sub-group received lithium chloride (127mg/kg) subcutaneously 24hours prior pilocarpine administration. Pilocarpine (30mg/kg) was administered intraperitoneally. After seizure onset (90minutes), the experimental rats received diazepam (10mg/kg). The brains were excised and fixed in 10% neutral buffered formalin. Brain slices were obtained at the optic chiasm for routine paraffin embedding. Neuroarchitecture of the cortex was investigated using Hematoxylin and eosin (H&E) stains, while the morphology of white matter and the corpus callosum was demonstrated using Luxol fast blue. Results: Different layers of the cerebral cortex showed neurodegenerative characteristics in all three groups, with severe neurodegeneration in experimental sub-group compared to control and sham sub-groups. Subcortical white matter displayed non-compactness of the myelin sheath, resulting in greater white matter thickness in the experimental sub-groups compared to the compact myelin sheath found in control and sham. Conclusion: Conclusively, progressive neurodegeneration observed in the cerebral cortex as well as the demylineation dynamics seen in subcortical white matter further explains the scientific basis of epileptogenesis following lithium-pilocarpine-induced TLE.

Keywords: TLE, lithium-pilocarpine, epileptogenesis, demyelination.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database