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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



R. R. Thenge*, G. D. Mehetre and V. S. Adhao


The main objective of the studies described was to develop a time-controlled release formulation based on a press-coating technique. The intention was that the formulation is administered in the evening at 22:00, which provides treatment for diseases in which symptoms are experienced in the early morning hours (i.e. chronopharmacotherapy). The Diclofenac potassium pressed coated tablets were prepared using direct compression method. The coats contained a hydrophilic polymer (hydroxypropylmethylcellulose) to control drug release. Cores were immediate-release formulations containing all or most of the drug dose. The time-controlled release dosage form containing HPMC allows time to peak plasma level to be adjusted to 6 to 8 hours after administration. Amount of HPMC used, HPMC viscosity grades selected were most important factors controlling drug release and absorption from the dosage form. The pressed coated tablets were evaluated for post compression studies such as hardness, friability, drug content, weight variation and dissolution studies. The kinetic data also applied to the dissolution. All the prepared tablets formulations were found to be good without capping and chipping. Post Compressionalparameters (hardness, friability, thickness and drug content) was within the acceptable limit. FTIR Spectroscopicstudies indicated that the drug is compatible with all the excipients. The in vitro drug release of polymer coated tablet of Diclofenac Potassium prepared by direct compression F2 method were found to be 96.60% at 8 hrs. Among the all formulations F2 formulation was found to be promising with controlled drug release. The inner Core tablets prepared with Superdisintegrant exhibited good disintegration characteristics. tablets having CP as the disintegrant showed faster dissolution rates and higher efficiency values.

Keywords: Diclofenac potassium, Compression coated, Tablets, FTIR, HPMC, Crosspovidone.

[Full Text Article]




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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database