EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

COMPARATIVE STUDY ON COMBINED EFFECT OF TREADMILL EXERCISE TEST AND HYPOTHYROIDISM ON OXIDATIVE STRESS OF SUB-CLINICAL AND OVERT HYPOTHYROIDISM PATIENTS

*Dr. Dilnawaz Ahmed, Dr. Surajit Kumar Mukhopadhyay and Dr. Srila Ghosh Chowdhury

ABSTRACT

Background: The present study was conducted on patients suffering from subclinical and over hypothyroidism and healthy controls. Materials and methods: The sample size was calculated to be 100 (50 cases and 50 healthy controls). They were recruited from the outpatient department with history of overt or subclinical hypothyroidism with no clinical evidence of CAD. Thyroid related parameters (FT4 and TSH) and cardiac parameters (SBP, DBP, PR, ECG HR, QRS) and oxidative stress biomarker (pre-TET MDA and post-TET MDA) were measures and correlated. Results: The mean FT4 was 0.80±0.23 in the case group and 0.75±0.30 in the control group. The TSH was 13.32±9.71 in the case group and 3.19±4.26 in the control group. The pre-TET MDA was 18.74±6.56 in the case group and 3.30±0.72 in the control group. The post-TET MDA was 20.62±6.56 in the case group and 5.45±0.89 in the control group. Statistically significant difference exists between the groups (p value≤0.05). Conclusion: The present study shows that there is a positive correlation between FT4 and post- TET MDA and a positive correlation between TSH and post-TET MDA. That means, oxidative stress as well as MDA levels will increase if there is any increase in the FT4 level and TSH level.

Keywords: Sub-clinical hypothyroidism, overt hypothyroidism, treadmill exercise test, FT4, TSH.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database