EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PHYTOCHEMICAL SCREENING, ACUTE TOXICITY AND ANTI-INFLAMMATORY EFFECT OF CHRYSOPHYLLUM WELWITSCHII (ENGL.) LEAF EXTRACT IN RAT

Agnero Sié Melchor*, Yéo Dodehe, Ouattara Karamoko, Yapi Houphouet F., N’guessan Jean D., Djaman Allico Joseph

ABSTRACT

The aqueous and alcoholic extracts contained flavonoids, tannins, alkaloids, sterols and terpenes, anthocyanins, saponins and cardiotonic glycosides. The water extract from the leaves of Chrysophyllum welwitschii (CHRYSOW) was evaluated for its acute toxicity in female rats. For the study of acute toxicity, oral doses of 300, 2000 and 5000 mg/kg of body weight was administered orally in rats. The results showed no signs of toxicity such as general behavior change; no morbidity and mortality. Both extracts of CHRYSOW were hardly toxic and their LD50 was higher than 5000mg/kg bw. The aqueous and ethanolic extracts of dried leaves of Chrysophyllum welwitschii Engl. was tested for anti-inflammatory action by carrageenan induced paw edema. The anti-inflammatory degree observed with aqueous extract revealed a higher anti-inflammatory activity than ethanolic extract. The aqueous extract in doses of 250 and 500 mg/kg of body weight showed 43.94 and 56.31% inhibition of paw edema, respectively at the end of 5 hours. The dose of 500 mg/kg of body weight was compared to that of standard dichlofenac sodium (56.92%). The anti-inflammatory activity may be due to presence of saponins, sterols and flavonoids in leaf extract.

Keywords: Chrysophyllum welwitschii, Extracts, Anti-inflammatory effect, Acute toxicity, LD50.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )