ANTI-HYPERTENSIVE ACTIVITY OF SIDDHA HERBO- MINERAL FORMULATION ELADHI CHOORANAM IN SPONTANEOUSLY HYPERTENSIVE RATS
Tamilselvan R.*, Bharathi K., Semalatha S.
Siddha drugs are currently very popular among the people. At the same time there has been an increase in the research of scientific siddha drugs. The reason is that it acts on diseases and cures them and causes fewer side effects. One of the secure and sinful anti-hypertensive Siddha medicine is Eladhi Chooranam (ECM). Which is used for this study to identify the anti- Hypertensive activity by using spontaneously hypertensive rats (SHR). Systolic blood pressure (SBP) and heart rate measurement of SH rats was carried out using tail-cuff method plethysmography (LE 5001 Pressure Meter). The SH rats were randomly divided in to four groups and each consists of six rats per group. All the groups were categorized into control, group received verapamil hydrochloride 12.5mg control, ECM 200mg and ECM 400mg. Test drug Eladhi chooranam was administrated (200mg/400mg/kg) orally. The systolic blood pressure (SBP) and heart rate (HR) of the rats were recorded. Administration of ECM for 28 days remarkably reduced the SBP and HR. The tidings obtained from this study shows decrease in Systolic BP and Heart Rate was more conclusive high dose level 400mg/kg than low dose 200mg/kg indicated bravery response to anti-hypertensive activity of the Siddha formulation Eladhi chooranam in a research-based way.
Keywords: Eladhi chooranam, Siddha, Anti-hypertensive, Spontaneously Hypertensive rat.
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