EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ENHANCEMENT OF WATER SOLUBILITY OF POORLY WATER SOLUBLE DRUGS: A REVIEW

Renu Tiruwa*, Ashutosh Badola,

ABSTRACT

The solubility of a substance (solute) is the maximum quantity of solute that can dissolve in a certain quantity of solvent at a specified temperature and pressure. In the other words the solubility can be define as the ability of one substance to form a solution with another substance in which one is solute and another is solvent. The substance to be dissolved is called as solute and the dissolving fluid in which the solute dissolve is called as solvent, which together form a solution.[1] Solubility, dissolution of solute in solvent to give a homogenous system, is important parameters to achieve desired concentration of drug in systemic circulation for pharmacological response. Today Poorly soluble drugs are problem in pharmaceutical formulations, poor solubility, making them poor candidates as new drugs. And about 40% drugs from newly developed chemical entities are lipophilic in nature and fail to reach market due to poor water solubility. The poor solubility of drugs remains one of the most challenging aspects in formulation development. We can overcome from this problem by combinatorial chemistry and various methods to improve the dissolution of poorly soluble drugs. It needs to improve the solubility and dissolution rate for poorly soluble drugs because these drugs possess low absorption and bioavailability.[2] Any drug to be absorbed must be present in an aqueous solution at the site of absorption. The oral route of administration is the most preferred and widely acceptable due to ease of ingestion for many drugs. Drugs with slow dissolution rate show the incomplete absorption leading to low bioavailability by oral administration. Various techniques are used for the improvement of the solubility of poorly water soluble drugs.

Keywords: .


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )