( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57



Dr. Naznin Nahar Momin*, Dr. M Shahab Uddin Aahmad, Mohammad Ismail Hossain, Dr. Sharmin Ashraf Rima, Dr. Taniza Farnaz and Dr. Mohammad Zillur Rahman


Thyroid nodules represent a wide spectrum of neoplasms with different biological behaviors and thyroid follicular epithelial carcinomas are the most common carcinoma of the endocrine system. Histological evaluation is the gold standard in the diagnosis of thyroid nodules, however, similar morphological features put a burden on pathologist while trying to make diagnosis on H & E slides. The use of immunohistochemical markers offers advantage in cases where histomorphological details are insufficient to establish a definitive diagnosis. The aim of this study to evaluate the role of HBME-1 in Differentiating Surgically Excised Thyroid Nodules. Immunohistochemistry method may plays a complementary role to clarify diagnostic dilemma. Materials and Methods: This is a cross sectional study which was conducted in the Department of Pathology, Chittagong Medical College, Chattogram during the period of March, 2019 to February, 2021 with 63 surgically excised thyroid nodule patients attending in Department of ENT, Chittagong Medical College Hospital and other private hospitals in chattogram. All collected samples were processed for routine histopathological study and selected for immunohistochemistry with HBME-1 antibody. Immunohistochemistry was done at Armed Forces Institute of Pathology, Dhaka Cantonment. Immunostaining was done by using primary antibody HBME-1 (Anti–Mesothelioma mouse monoclonal antibody HBME-1 1ab2383.Abcam, UK). Patient’s demographic data were collected and recorded in a pre-designed data sheet. Statistical analysis was carried out as required. Ethical practice was ensured in every step of the study. Results and observations: In this study the mean age was 39.47 ± 13.67 and male to female ratio was 1: 6.9. Thirty-four patients (76.3%) had multiple nodules and 29 patients had history of consuming iodized salt. Forty-three (68.3%) cases were histomorphologically diagnosed as benign and 20 cases (31.7%) as malignant thyroid nodules according to the 2017 WHO classification of thyroid tumors. In the study, HBME-1 positive expression was showed in 17 cases (85%) out of 20 cases of malignant nodules and expression was not observed in benign nodules. The expression of HBME-1 was not statistically significant (p>0.250) means no difference was observed between histopathological examination and HBME-1 expression for diagnosis of benign and malignant nodules. Conclusion: Positive HBME-1 staining is a strong indicator of malignancy, although negative staining does not rule it out. The utilization of HBME-1 markers along with histomorphological evaluation is supportive in the differential diagnosis of thyroid nodules.

Keywords: Thyroidnodules, lymphangiogenesis, metastasis.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia