EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

EFFECT OF VITAMIN E ON LIPID PROFILE OF ALBINO RATS INFECTED WITH TRYPANOSOMA BRUCEI

Adegoke O. Adebayo*, George –Opuda I.M. and Bamigbowu E.O.

ABSTRACT

This study was carried out to determine the effect of vitamin E on the lipid profile of male Wistar albino rats infected with Trypanosomabruceibrucei. 24 male Wistar albino rats were divided into 6 groups namely; Control (not infected not treated), Trypanosome infected, Diamenazene treated, 40mcg vitaminB12, 60mcg vitaminB12, 80mcg vitaminB12, The lipid profile indicators such as Triglycerides, Total cholesterol, High Density Lipoprotein and Low Density Lipoprotein were determined in all the albino rats using enzymatic methods while Low Density Lipoprotein was determined using Friedewald formula. The data was subjected to statistical analysis using SPSS version 20. The result showed a significant decrease (P<0.05) in the mean value ofTriglycerides (mg/dl), Cholesterol (mg/dl), HDL (mg/dl) and LDL (mg/dl) in trypanosome infected group (77.55±2.42, 51.88±2.20, 37.31±0.81 and 28.85±1.78) respectively when compared to the mean value of control group (99.03±6.66, 64.83±2.41, 39.87±0.27 and 38.03±2.81) respectively. The diamenazene treated group showed a significant decrease (p<0.05) in the mean value of Triglycerides (mg/dl), Cholesterol (mg/dl), HDL (mg/dl) and a significant increase in LDL (mg/dl) ( 52.93±2.76, 56.18±0.89, 35.26±1.00 and 38.38±0.86) respectively when compared to the mean value of control group (99.03±6.66, 64.83±2.41, 39.87±0.27 and 38.03±2.81) respectively.The Vitamin E treated group showed a significant decrease (p<0.05) in the mean value of Triglycerides (mg/dl) at dose of 0.1mg (63.13±7.59) ,0.5mg (96.05±0.80), 1.0mg (66.40±5.26) as compared to mean value of control group (99.03±6.66) and a significant increase in mean value of cholesterol (mg/dl) at dose of 0.5mg (70.85±4.54), 1.0mg (76.55±1.49), HDL (mg/dl) at dose of 0.5mg (42.04±2.26), 1.0mg (42.60±2.34) and LDL (mg/dl) at dose of 0.1mg (38.28±9.43), 0.5mg (43.23±4.17), 1.0mg (54.75±0.50) when compared to mean value of control group (64.83±2.41, 39.87±0.27 and 38.03±2.81) respectively. The result of the study showed that Vitamin E reversed the changes in lipid concentration cause by T brucei.

Keywords: Vitamin E, Trypanosomiasis, Lipids.

[Full Text Article] [Download Certificate]