LITERATURE REVIEW OF THE PROBLEM OF SPONTANEOUS BACTERIAL PERITONITIS IN LIVER CIRRHOSIS AND VIRAL ETIOLOGY

Khamdamov B.Z.* and Oblokulov A.A.

ABSTRACT

This review is devoted to the study of spontaneous bacterial peritonitis in liver cirrhosis of viral etiology. The results of the conducted studies serve as scientific confirmation of the infectious nature of SBP, its polyetiological nature, and also allow us to consider various variants of SBP as clinical and laboratory manifestations of a single pathogenetic process. There is a need for further research in the direction of studying the subtle mechanisms of pathogenesis, solving problems for the prevention and treatment of SBP. In the future, the use of genetically engineered cytokines (preparations of recombinant alpha- and gamma-interferons, recombinant colony-stimulating factors, some recombinant interleukins) may be pathogenetically justified and promising in the prevention and treatment of SBP in cirrhosis. This is due to the fact that in the processes of generalization of inflammation as a trigger for the formation of early multiple organ failure in sluggish purulent-inflammatory diseases, as in SBP, the failure of the immune system plays a leading role.

Keywords: liver cirrhosis, spontaneous bacterial peritonitis, cytokines, interleukins, viral hepatitis.