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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Asish Bhaumik*, SK. Nagulmeera, G. Neelamma, Sanjoy Das and K. Sreelatha


Punica granatum is grown as a fruit crop plant, and as ornamental trees and shrubs in parks and gardens. The edible fruit of Punica granatum is a berry and is between a lemon and a grapefruit in size, 5–12 cm in diameter with a rounded hexagonal shape and has thick reddish skin. The main aim and objectives of the present work was to isolate the bioactive molecules from the ethanolic extract of fruits Punica granatum (EEF-PG) and evaluate the in vivo hepatoprotective activity. The isolationation and characterization of biomolecules was carried out by ESI-MS-MS. In vivo hepatoprotective activity was performed against CCl4 induced rat hepatocytes. The Results displayed that the elevated levels of SGOT, SGPT, ALP and Serum bilirubin due to CCl4 intoxication were reduced significantly (*P<0.05) in rats, after treatment with EEF-PG. Treatment with EEF-PG at a both doses of 200 and 400 mg/kg b.w. significantly decreased the SGOT, SGPT, ALP, Serum Bilirubin levels by 10.76%, 23.30%, 10.18% and 36.98% (at low dose) and 25.33%, 42.26%, 22.66% and 54.79% (at high dose) respectively. Silymarin used as standard drug showed a reduction of 74.19%, 76.91%, 86.7% and 78.08% receiving CCl4 alone. So depending upon the experimental evidence, it was confirmed that the biochemical parameters of the group treated with EEF-PG was significantly lower than the CCl4-treated group. Histopathological examination of liver section of the rat treated with both 200 mg/kg, 400 mg/kg body weight of EEF-PG intoxicated with carbon tetrachloride had shown minimal inflammation with moderate portal triditis, moderate necrotic debris, centrilobular regeneration with restoration of central vein, sinusoids and hepatocytes with mild necrosis and their lobular architecture was normal.

Keywords: Bioactive molecules, Hepatoprotective activity, ESI-MS-MS, Portal triditis, centrilobular regeneration etc.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )