EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

AFRICAN WALNUT SEED OIL ENRICHED DIET REDUCES PROSTATE CANCER INCIDENCE IN WISTAR RATS

*Esosa Samuel Uhunmwangho, Onoriode Oyiborhoro and Osungbemiro Bamikole Walter

ABSTRACT

African Walnut (Tetracarpidium conophorum- Mull. Arg) is a perennial climbing shrub which grows mainly in West Africa, especially in Nigeria. The seeds are commonly processed by boiling and consumed as a snack. This study investigated the possible inhibition of 3-methylcholanthrene (MC) induced prostatic carcinogenesis and expression level of ethoxyresorufin-O-de-ethylase (CYP1A1), benzoxyresorufin-O-dealkylase (CYP1B1) and pentoxyresorufin-O-dealkylase (CYP2B1) activities by African walnut seed oil extract in male Wistar rats. The seed oil was extracted with n-hexane using Soxhlet apparatus. 60 Wistar rats of an average weight of 40-45g were randomly divided into four major groups of 15 rats each. Group A and B animals were fed for 12weeks with diet containing 10% of African walnut seed oil. Group C and D were fed for 12weeks with diet containing no African walnut seed oil. Group B and C animals were administered with 3-methylcholanthrene (200mg/kg) intraperitoneally after 4weeks of feeding. Results showed that group B had a significant decrease in the expression of CYP1A1, CYP1B1 and CYP2B1 enzymes (p<0.05) compared to group C. Prolonged latency period, reduce tumor weight and size characterized animals in group B. Histological analysis of the liver revealed that the progression of carcinogenesis was more rapid in animals that were not pretreated with African walnut seed oil, which is indicative that African walnut seed oil enriched diet oppose prostate carcinogenesis induced by MC.

Keywords: 3-methylcholanthrene, African walnut, Prostate gland, Cytochrome-P450.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database