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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



M. Samutirika Devi, N. S. Raghupathy, M. Mathivanan and M. Srilakshmi Chordia*


Background and Aim: Determination of early fetal growth abnormalities is one of the most important aspects of antenatal healthcare. In this study, we attempted to sonographically assess the correlation of early first trimester (>8 to <11 weeks) crown-rump length (CRL)with birth weight. Method: A prospective observational study with 252 women (19-39 years) having uneventful pregnancies were assessed for CRL during the early first trimester sonographically and followed up till delivery. The birth weight of their respective newborn was categorized into Small for Gestational Age (SGA), Appropriate for Gestational Age (AGA) and Large for Gestational Age (LGA). Both variables were correlated and analysed using SPSS 21.0 software. Analysis of variance (ANOVA), independent ‘t’-test, kappa-coefficient, Pearson bivariate correlation and linear regression were performed. Results: Mean early first-trimester CRL was 26.24±8.41 mm. There was a significant incremental trend of CRL with gestational age. The first-trimester CRL predicted AGA in 203 (80.6%), SGA in 37 (14.7%) and LGA in 12 (4.8%) pregnancies. At delivery, 205 (81.3%) were AGA, 35 (13.9%) were SGA and 12 (4.8%) were LGA. Agreement between estimated and actual growth categories was observed in 228/252 (90.5%) cases. Sensitivity, specificity, PPV, NPV and accuracy of CRL based estimations of birth weight category were 93.7%, 76.6%, 94.6%, 73.5%, 92.1% for AGA, 80%, 95.9%, 75.7%, 95.9%, 93.7% for SGA and 66.7%, 98.3%, 66.7%, 98.3% 96.8% for LGA. Conclusion: The findings of this study suggest that early first-trimester CRL can be used for the prediction of birth weight in uncomplicated pregnancies.

Keywords: Early first-trimester, Crown-rump length, Sonography, birth weight, SGA, AGA, LGA.

[Full Text Article]




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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database