FORMULATION AND CHARACTERIZATION OF SUPPOSITORIES OF HESPERIDIN

Khushbu G. Rahangdale*, Dnyanesh N. Dahake, Durgeshwari R. Misar, Pranjali B. Nakhate, Nikhita E. Parkhi and Pooja H. Sonewane

ABSTRACT

Rectal drug delivery has several advantages such as reduced hepatic first pass elimination of high clearance drug, avoidance of gastric irritation associated with certain drugs in case of nausea, vomiting, and when the patient is unconscious. The objective of this work is to formulate suppositories of hesperidin obtained from peels of citrus fruit to treat hemorrhoids. Method: For the preparation of the suppository we use the hot melt method. In this method, hesperidin is used as an active ingredient. polyethylene glycol 400, polyethylene glycol 6000 as a water-soluble base. The macro melting range, liquefaction time, mechanical strength, and content uniformity test are characterized. All the suppositories were free from pits, fissures, and cracks. The longitudinal section of the suppository was plain and clear, indicating the dissolution of the drug in the base. The drug content was found to be 97.34 % which is within the acceptable range liquefaction time was found to be 17 minutes at 370c. The temperature for macro melting was found to be 32ºC. The hesperidin suppository prepared by this method meets the quality requirement of the suppository and may be developed as a new formulation of hesperidin.

Keywords: Hesperidin suppository, Hemorrhoid, Anti-inflammatory, Anti-microbial, Polyethylene Glycol, Hot melt method.