EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION AND CHARACTERIZATION OF SUPPOSITORIES OF HESPERIDIN

Khushbu G. Rahangdale*, Dnyanesh N. Dahake, Durgeshwari R. Misar, Pranjali B. Nakhate, Nikhita E. Parkhi and Pooja H. Sonewane

ABSTRACT

Rectal drug delivery has several advantages such as reduced hepatic first pass elimination of high clearance drug, avoidance of gastric irritation associated with certain drugs in case of nausea, vomiting, and when the patient is unconscious. The objective of this work is to formulate suppositories of hesperidin obtained from peels of citrus fruit to treat hemorrhoids. Method: For the preparation of the suppository we use the hot melt method. In this method, hesperidin is used as an active ingredient. polyethylene glycol 400, polyethylene glycol 6000 as a water-soluble base. The macro melting range, liquefaction time, mechanical strength, and content uniformity test are characterized. All the suppositories were free from pits, fissures, and cracks. The longitudinal section of the suppository was plain and clear, indicating the dissolution of the drug in the base. The drug content was found to be 97.34 % which is within the acceptable range liquefaction time was found to be 17 minutes at 370c. The temperature for macro melting was found to be 32ºC. The hesperidin suppository prepared by this method meets the quality requirement of the suppository and may be developed as a new formulation of hesperidin.

Keywords: Hesperidin suppository, Hemorrhoid, Anti-inflammatory, Anti-microbial, Polyethylene Glycol, Hot melt method.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database