FORMULATION AND EVALUATION OF GASTRO RETENTIVE FLOATING TABLET OF ROSUVASTATIN
Mohammed Gulzar Ahmed*, Sanjana. A and Vinay C.H.
The aim of the present study was to develop a Gastro retentive floating tablets (GRFT) of Rosvastatin was developed by direct compression method, by using drug with different polymer ratio like HPMC E50, HPMC K15M, HPMC 5cps. The formulation were evaluated for their physical characteristics, viz., hardness, friability, drug content and floating properties. Further the tablets were studied for in vitro drug release characteristics for 12 h. The tablets exhibited controlled and prolonged drug release, with optimum hardness, consistent uniformity in weight and low friability. The formulation with F2 showed 99% drug release at the end of 12 h and exhibited optimum floating lag time. A decrease in release rate of the drug was observed by increasing viscosity grades of the polymer (HPMC). Drug release from effervescent floating matrix tablets was sustained over 12 h with buoyant properties. FTIR study revealed that there is no drug excipients interaction. Based on the release kinetics, all formulations best fitted the Higuchi, first-order model and non-Fickian as the mechanism of drug release.
Keywords: Rosvastatin, Direct compression, HPMC E50, HPMC K15M, HPMC 5cps.
[Full Text Article]