EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

SUBACUTE TOXICITY OF AQUEOUS AND ETHANOLIC EXTRACTS OF STEM BARK FROM Trichilia emetica (Meliaceae)

*Djoupo Agnon Prisca, Djyh Bernard Nazaire, Ayebé Edwige Kouadio, Boga Gogo Lucien, Bamba Abou, Zaza Henri Venance and Yapi Houphouët Félix

ABSTRACT

Trichilia emetica is a tropical plant widly found in sub-saharan Africa. Therapeutic use of various parts of this plant has been mentioned in many traditional medicinal systems. Owing to their safety profiles, the aim of the present study was to evaluate subacute toxicity of ethanolic and aqueous extracts of steem bark of Trichilia emetica. Serial extraction was done using ethanol and water as solvents. The study was evaluated by daily doses of extracts 500, 800 and 1100 mg/kg orally for 28 days to groups of 6 animals per group including 3 males and 3 females. The control group received no extract. Animals were observed for general behavioral and signs of abnormalities during the experiment duration. The last day, blood was taken for hematological and biochemical analysis. The liver, kidney, and heart tissues were weighed. The results showed that, there were no significant (p˃0,05) changes in both the asolute and relative organ weights between the control and the test groups. Biochemical parameters were statistically equal in all groups. In addition, both extracts did not cause any significant effect on RBC and indices relating to it (Hb, PCV, MCV, MCH and MCHC) throughout the experimental period. But, there was a significant decrease on WBC and percentage of total lymphocytes cells with ethanolic extract at dose of 1100 mg/kg b.w. In conclusion, the ethanolic and aqueous extracts of steem bark from Trichilia emetica did not produce any toxicity in oral suba-cute toxicity study. However, further studies are needed to confirm long term toxicities.

Keywords: subacuty, Trichilia emetica, Haematological and biochemical parameters.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )