( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



*Sunaina Anand, Anish Desai and Shreya A. Jog


Several studies have found vitamin C or Ascorbic acid therapy effective to treat cancer of lungs, liver, pancreas, ovaries, mesothelioma, sarcoma, prostate. Cancer cells are unable to grow at high vitamin C concentration and possibly it may cause tumour shrinkage. It is shown to have number of benefits in reducing cholesterol, neutralises free radicals, promotes collagen, breakdown of histamine, reduces risk of premature death etc. There are several pathways like epigenetic, antioxidant, chemopreventive, immunologic, collagen, and “adjuvant” anticancer effect that vitamin C undergoes during cancer treatment. Parenteral transfusion of vitamin C is believed to be selective as cancer cells have a low level of antioxidant enzyme like catalase, superoxide dismutase, and glutathione peroxidase than normal cells. In the cytosole dehydroascorbic acid (DHAA) is converted to vitamin C that depletes glutathione (GSH) and causes redox imbalance and oxidative stress. Oxidative stress triggers a cascade of processes that include glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inactivation, glycolysis inhibition, and energy crisis, all of which culminate in cancer cell death. Vitamin C combined with chemotherapy perquisites in enhancement of chemotherapy, low toxicity, suppress tumour, and improve quality of life. Ascorbic acid is contraindicated in glucose-6-phosphate dehydrogenase (G6PD) and hemochromatosis. Clinical trials have shown that ascorbic acid is well tolerated with conventional anti-cancer drugs, reduces anti-cancer drug related toxicity. High-dose vitamin C increases radiosensitivity of glioblastoma multiforme cells, causing more cell death as compared to radiation.

Keywords: epigenetic, antioxidant, chemopreventive, immunologic, collagen, and “adjuvant”.

[Full Text Article]




    JANUARY issue has been successfully launched on 1 JANUARY 2023.

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database